Science at Yale-NUS College is supported by a wide range of specialised laboratories, scientific equipment, field resources, and computing infrastructure. 

The College has three behavioural laboratories, which are used by students and faculty who conduct experimental psychology, human-computer interaction, or human neuroscience research.

The College has two Makerspaces, Fabrication Studios 4 and 5, to support faculty and students in curricular projects, prototyping, research, and experimentation.